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A complete of three % of active substance is excreted in urine as unchanged active compound. Tapentadol is Moreover metabolised to N-desmethyl tapentadol (13 %) by CYP2C9 and CYP2C19 also to hydroxy tapentadol (two %) by CYP2D6, which happen to be further more metabolised by conjugation. Thus, Lively compound metabolism mediated by cytochrome P450